First of all there's this little bit of loveliness from yesterday's trailer clearly showing the infamous tentacles of Doc Ock.
Then, earlier today, actor B.J. Novak (The Office), in an interview with The Huffington Post, teased his role in the film. When asked if his role was a secret, Novak replied, "No. I'm in a couple of scenes. Yeah, I was never told whether or not I could say. I can say that work at OsCorp. And I am someone from the comic books, someone from the original. So, yeah, I'm somebody. I wouldn't say I'm pivotal, but I'm not an extra either."
With all the speculation of The Sinister Six appearing in this or the next Spidey film, it's quite possible that Novak is playing Doc Ock. The picture above isn't too far off of what he might look like.